The immune complex CTA1-DD/IgG adjuvant specifically targets connective tissue mast cells through FcγRIIIA and augments anti-HPV immunity after nasal immunization
نویسندگان
چکیده
منابع مشابه
Mast cells contribute to the mucosal adjuvant effect of CTA1-DD after IgG-complex formation.
Mast cell activation is one of the most dramatic immune-mediated responses the body can encounter. In the worst scenario (i.e., anaphylaxis), this response is fatal. However, the importance of mast cells as initiators and effectors of both innate and adaptive immunity in healthy individuals has recently been appreciated. It was reported that mast cell activation can be used as an adjuvant to pr...
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چکیده ندارد.
15 صفحه اولMast cells in the inflammatory connective tissue diseases
Objective: To detect mast cells in normal human skin and mast cell infiltration in skin biopsies in patients with systemic sclerosis, systemic lupus erythematosus, Raynaud’s phenomenon, and persons not suffering from any systemic disease. Material and methods: Paraffin histological sections were stained with toluidine blue and by immunoperoxidase method for the von Willebrand factor. Results: I...
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Mast cells are the sentinels of immune systems and, like other immuno-competent cells, they are produced by hematopoietic stem cells. We analyzed the expression of signal transducer and activator of transcription 4 (Stat4), and investigated its role in mast cells. Murine mast cells are usually divided into 2 distinct populations by their distribution and contents of their granules: mucosal mast...
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ژورنال
عنوان ژورنال: Mucosal Immunology
سال: 2013
ISSN: 1933-0219,1935-3456
DOI: 10.1038/mi.2013.16